I’m delighted to share the work led by Yunbing Shen, with help from especially Long Jiang and Vaishnavi Iyer.
“A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system”
Paper: https://tinyurl.com/4sedjhtm
Linked soundtrack: https://tinyurl.com/5465m73y
CRISPR never generates a uniform genotype which complicates analyzing the targeted gene’s role without establishing clonal lines. Here we give examples of how the generated genetic heterogeneity can be leveraged for discovery –> RCC!
See Twitter threed for more info –> https://twitter.com/Wermeling_lab/status/1452537209320583173
The Wermeling lab at the Karolinska Institutet 