Projects

  • CRISPR-based studies of pathogenic neutrophil behavior.

  • Identification of drug targets related to autoreactive T cells in the context of autoimmune joint inflammation.

  • Therapeutic antibody treatment for cancer; a role for different myeloid suppressor cells and IL-4R signaling.

  • Studies related to expansion, and CRISPR-based modification of hematopoietic stem cells.

  • Custom CRISPR/Cas9 screens to identify drug targets in inflammatory diseases and cancer.

     

Illustration: Marek Skupiniski

Outline CRISPR screen experimental setup:

crispr screen for homepage