Link to publications on PubMed here.
Link to Google Scholar profile here.
Link to thesis (2010) "Innate Mechanisms Regulating Peripheral B cell Tolerance" here.
Link to patent "Anti-inflammatory agents" here.
Link to popular scientific texts and interviews here.
Link to plasmids we deposited to Addgene here.
Original articles and reviews (* = corresponding author)
1. Non-invasive PET detection of CD69 positive immune cells before signs of clinical disease in inflammatory arthritis
Puuvuori E, Shen Y, Hulsart-Billström G, Mitran B, Zhang B, Cheung P, Wegrzyniak O, Ingvast S, Persson J, Ståhl S, Korsgren O, Löfblom J, WERMELING F*, Eriksson O*
J Nucl Med. 2024 Feb 1;65(2):294-299. doi: 10.2967/jnumed.123.266336. PMID: 38050119 Link
2. High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.
Zaghmi A, Aybay E, Jiang L, Shang M, Steinmetz-Späh J, WERMELING F, Kogner P, Korotkova M, Östling P, Jakobsson PJ, Seashore-Ludlow B, Larsson K.
Mol Oncol. 2023 Jul 30. doi: 10.1002/1878-0261.13502. PMID: 37519014
Link
3. MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia.
Lerma Clavero A, Boqvist PL, Ingelshed K, Bosdotter C, Sedimbi S, Jiang L, WERMELING F, Vojtesek B, Lane DP, Kannan P.
Sci Rep. 2023 Mar 20;13(1):4583. doi: 10.1038/s41598-023-31484-0. PMID: 36941277. Link
4. Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development.
Raposo B, Afonso M, Israelsson L, Wähämaa H, Stålesen R, WERMELING F, Hensvold AH, Grönwall C, Rethi B, Klareskog L, Malmström V.
Ann Rheum Dis. 2023 May;82(5):724-726. doi: 10.1136/ard-2022-223417. Epub 2023 Jan 5. PMID: 36604150. Link
5. Biosynthesis of prostaglandin 15dPGJ2 -glutathione and -cysteine conjugates in macrophages and mast cells via MGST3: Biosynthesis of 15dPGJ2-conjugates.
Steinmetz-Späh J, Liu J, Singh R, Ekoff M, Boddul S, Tang X, Bergqvist F, Idborg H, Heitel P, Rönnberg E, Merk D, WERMELING F, Haeggström JZ, Nilsson G, Steinhilber D, Larsson K, Korotkova M, Jakobsson PJ.
J Lipid Res. 2022 Nov 9:100310. doi: 10.1016/j.jlr.2022.100310. PMID: 36370807. Link
6. Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis.
Sakuraba K, Krishnamurthy A, Sun J, Zheng X, Xu C, Peng B, Engström M, Jakobsson PJ, WERMELING F, Catrina S, Grönwall C, Catrina AI, Réthi B.
J Autoimmun. 2022 Sep 13;133:102903. doi: 10.1016/j.jaut.2022.102903. PMID: 36108504. Link
7. The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy.
Ingelshed K, Spiegelberg D, Kannan P, Påvénius L, Hacheney J, Jiang L, Eisinger S, Lianoudaki D, Lama D, Castillo F, Bosdotter C, Kretzschmar WW, Al-Radi O, Fritz N, Villablanca EJ, Karlsson MCI, WERMELING F, Nestor M, Lane DP, Sedimbi SK.
Cancer Research Communications (2022) 2 (9): 1075–1088. DOI: https://doi.org/10.1158/2767-9764.CRC-22-0053. Link
8. Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2
Iyer VS, Boddul SV, Johnsson AK, Raposo B, Sharma RK, Shen Y, Kasza Z, Lim KW, Chemin K, Nilsson G, Malmström V, Phan AT, WERMELING F*
J Autoimmun. 2022 Jul;131:102857. Link
Linked soundtrack: Spotify
9. A CRISPR-p53 interactome with potential implications for clinical CRISPR/Cas9 use
Jiang L, WERMELING F*
Oncoscience. 2022 May 9;9:27-29. Link
10. Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis
Sharma RK, Boddul SV, Yoosuf N, Turcinov S, Dubnovitsky A, Kozhukh G, WERMELING F, Kwok WW, Klareskog L, Malmström V
Sci Rep. 2021 Dec 31;11(1):24512. Link
11. CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
Jiang L, Ingelshed K, Shen Y, Boddul SV, Iyer VS, Kasza Z, Sedimbi S, Lane DP, WERMELING F*.
Cancer Res. 2021 Nov 8;canres.1692.2021. Link
Linked soundtrack: Spotify
Press release: https://news.ki.se/new-findings-on-the-link-between-crispr-gene-editing-and-mutated-cancer-cells
Twitter thread: https://twitter.com/Wermeling_lab/status/1462857299073114119
12. Shen Y, Jiang L, Iyer VS, Raposo B, Boddul SV, Kasza Z, WERMELING F*.
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Comput Struct Biotechnol J. Volume 19, 2021, Pages 5360-5370 link
Linked soundtrack: Spotify
Twitter thread: link
13. Kumar S, Koenig J, Schneider A, WERMELING F, Boddul S, Theobald SJ, Vollmer M, Kloos D, Lachmann N, Klawonn F, Lienenklaus S, Talbot SR, Bleich A, Wenzel N, von Kaisenberg C, Keck J, Stripecke R.
In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution
Biomedicines. 2021 Aug 5;9(8):961. link
14. Boddul SV, Sharma RK, Dubnovitsky A, Raposo B, Gerstner C, Shen Y, Iyer VS, Kasza Z, Kwok WW, Winkler AR, Klareskog L, Malmström V, Bettini M, WERMELING F*.
In vitro and ex vitro functional characterization of human HLA-DRB1*04 restricted T cell receptors.
J Transl Autoimmun. Transl Res. 2021 Mar;229:69-82. link
15. Sundström Y, Shang MM, Panda SK, Grönwall C, WERMELING F, Gunnarsson I, Lundberg IE, Sundström M, Jakobsson PJ, Berg L.
Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay.
Transl Res. 2021 Mar;229:69-82. link
16. Iyer VS, Jiang J, Shen Y, Boddul SV, Panda SK, Kasza Z, Schmierer B, WERMELING F*
Designing custom CRISPR libraries for hypothesis-driven drug target discovery (review)
Comput Struct Biotechnol J. 2020 Aug 18;18:2237-2246. link
17. Panda SK, Wigerblad G, Jiang L, Jiménez-Andrade Y, Iyer VS, Shen Y, Boddul SV, Guerreiro-Cacais AO, Raposo B, Kasza Z, WERMELING F*.
IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3103-3113. link, PDF
Press release: https://news.ki.se/proteins-that-protect-against-joint-inflammation-identified
18. Xu X, Makaraviciute A, Abdurakhmanov E, WERMELING F, Li S, Danielson HU, Nyholm L, Zhang Z
Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses.
ACS Sens. 2020 Jan 24;5(1), 217-224. link
19. Schulz A, Jiang L, de Vor L, Ehrström M, WERMELING F, Eidsmo L, Melican K.
Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization.
Cell Rep. 2019 Oct 29;29(5):1074-1081.e5. link
20. Record J, Sendel A, Kritikou JS, Kuznetsov NV, Brauner H, He M, Nagy N, Oliveira MMS, Griseti E, Haase CB, Dahlström J, Boddul S, WERMELING F, Thrasher AJ, Liu C, Andersson J, Claesson HE, Winqvist O, Burns SO, Björkholm M, Westerberg LS.
An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma.
Haematologica. 2019 Oct 3. pii: haematol.2019.216317. link
21. Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, Sandor K, Xu B, Abdelmoaty S, Hunt MA, Ängeby Möller K, Baharpoor A, Sinclair J, Jardemark K, Lanner JT, Khmaladze I, Borm LE, Zhang L, WERMELING F, Cragg MS, Lengqvist J, Chabot-Doré AJ, Diatchenko L, Belfer I, Collin M, Kultima K, Heyman B, Jimenez-Andrade JM, Codeluppi S, Holmdahl R, Svensson CI.
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
J Exp Med. 2019 Aug 5;216(8):1904-1924. link
22. Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, WERMELING F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG.
Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Circulation. 2019 May 21;139(21):2466-2482. link
Press release here
23. Lloyd KA, Wigerblad G, Sahlstrom, P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou DN, Stalesen R, Ossipova E, Lundqvist C, Ekwall O, Ronnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, WERMELING F, Malmstrom V, Gronwall C.
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Front Immunol. 2019 Jan 4;9:3033. link
24. Parodis I, Söder F, Faustini F, Kasza Z, Samuelsson I, Zickert A, Svenungsson E, van Vollenhoven RF, Malmström V, WERMELING F, Gunnarsson I.
Rituximab-mediated late-onset neutropenia in systemic lupus erythematosus - distinct roles of BAFF and APRIL.
Lupus. 2018 Aug;27(9):1470-1478. link
25. Habir K, Aeinehband S, WERMELING F, Malin S.
A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation.
Front Immunol. 2017 Oct 24;8:1387. link
26. Panda, SK, Boddul S, Jiménez-Andrade G, Jiang L, Kasza Z, Fernandez-Ricaud L and WERMELING F*.
Green Listed – A CRISPR Screen Tool.
Bioinformatics. 2017 Apr 1;33(7):1099-1100. link, PDF
Press release: https://news.ki.se/new-software-makes-crispr-methodology-easier
27. Duhlin A, Chen Y, WERMELING F, Sedimbi SK, Lindh E, Shinde R, Halaby MJ, Kaiser Y, Winqvist O, McGaha TL, Karlsson MC.
Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.
J Immunol. 2016 Oct 1;197(7):2618-26. link
28. Kritikou JS, Dahlberg C, Baptista MA, Wagner AK, Banerjee PP, Gwalani LA, Poli C, Panda SK, Kärre K, Kaech SM, WERMELING F, Andersson J, Orange JS, Brauner H, Westerberg LS.
IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.
Sci Rep. 2016 Aug 1;6:30636. link
29. Prokopec KE, Georgoudaki AM, Sohn S, WERMELING F, Grönlund H, Lindh E, Carroll MC, Karlsson MC.
Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.
J Immunol. 2016 Sep 15;197(6):2063-8. link
30. Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, Iwata Y, Almer S, Söderman J, Toftgård R, WERMELING F, Boström EA, Boström PA.
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
Nat Commun. 2016 Apr 12;7:11314. link
31. Siegmann N, Worbs D, Effinger F, Bormann T, Gebhardt M, Ulrich M, WERMELING F, Müller-Hermelink E, Biedermann T, Tighe M, Edwards MJ, Caldwell C, Leadbetter E, Karlsson MCI, Becker KA, Gulbins E, and Döring G.
Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis.
Cell Physiol Biochem. 2014;34(1):56-70. link
32. WERMELING F, Anthony RM, Brombacher F, and Ravetch JV.
Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling.
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13487-91. link, PDF
33. Lindh E, Brännström J, Jones P, WERMELING F, Hässler S, Betterle C, Garty BZ, Stridsberg M, Herrmann B, Karlsson MCI, Winqvist O.
Autoimmunity and cystatin SA 1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.
J Autoimmun. 2013 May;42:1-6. link
34. Anthony RM, WERMELING F and Ravetch JV.
Novel roles of the IgG Fc glycan (review)
Ann N Y Acad Sci. 2012 Apr;1253:170-80. link
35. Anthony RM, Kobayashi T, WERMELING F and Ravetch JV.
Intravenous gammaglobulin suppresses inflammation through a Novel TH2 Pathway.
Nature. 2011 Jun 19;475(7354):110-3. link
36. Jordö ED, WERMELING F, Chen Y and Karlsson MCI.
Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity (review)
Mol Immunol. 2011 Jun;48(11):1307-18. link
37. Sakthivel P, WERMELING F, Elmgren A, Hulthe J, Kakoulidou M, Lefvert AK and Lind L.
Circulating soluble CTLA-4 is related to inflammatory markers in the 70 year old population.
Scand J Clin Lab Invest. 2010 Jul;70(4):237-43. link
38. WERMELING F, Lind S. M, Domange Jordö E., Cardell S, Karlsson MCI.
Invariant NKT cells limit activation of autoreactive CD1d positive B cells.
J Exp Med. 2010 May 10;207(5):943-52. link, PDF
[Highlighted in Nat Rev Immunol. 2010 Jun;10(6):384 link]
39. Chen Y, WERMELING F, Sundqvist J, Jonsson AB, Tryggvason K, Pikkarainen T and Karlsson MCI.
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.
Eur J Immunol. 2010 May;40(5):1451-60. link
40. WERMELING F, Karlsson MC, McGaha TL.
An anatomical view on macrophages in tolerance (review)
Autoimmun Rev. 2009 Sep;9(1):49-52. link
41. Thunberg S, Neimert-Andersson T, Cheng Q, WERMELING F, Bergström U, Swedin L, Dahlén SE, Arnér E, Scheynius A, Karlsson MC, Gafvelin G, van Hage M, Grönlund H.
Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice.
Allergy. 2009 Jun;64(6):919-26. link
42. Anthony RM, WERMELING F, Karlsson MC, Ravetch JV.
Identification of a receptor required for the anti-inflammatory activity of IVIG.
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19571-8. link
43. Westerberg LS, de la Fuente MA, WERMELING F, Ochs HD, Karlsson MC, Snapper SB, Notarangelo LD.
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.
Blood. 2008 Nov 15;112(10):4139-47. link
44. WERMELING F, Chen Y, Pikkarainen T, Scheynius A, Winqvist O, Izui S, Ravetch JV, Tryggvason K, Karlsson MC.
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus.
J Exp Med. 2007 Oct 1;204(10):2259-65. link, PDF
[Highlighted in Nat Clin Pract Rheumatology, 2008, 4:7]
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