Great work by Sanjay Boddul in the lab developing methods to study T cell receptors cloned from patients! The presented experimental pipeline enables rapid development of relevant humanized animal models for studying novel antigen-specific tolerance therapeutics.
Boddul SV, Sharma RK, Dubnovitsky A, Raposo B, Gerstner C, Shen Y, Iyer VS, Kasza Z, Kwok WW, Winkler AR, Klareskog L, Malmström V, Bettini M, Wermeling F.
In vitro and ex vivo functional characterization of human HLA-DRB1*04 restricted T cell receptors.
J Transl Autoimmun. 2021 March (Accepted). link
The Wermeling lab at the Karolinska Institutet 