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The Wermeling lab at the Karolinska Institutet

– Research related to Autoimmunity, Cancer immunotherapy, hematopoiesis, and CRISPR/Cas9

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Nucleosomes block access of CRISPR/Cas9 to DNA – Important study from the Weissman lab

Nucleosomes impede Cas9 access to DNA in vivo and in vitro.

Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS.

Elife. 2016 Mar 17;5. pii: e12677. doi: 10.7554/eLife.12677.

PMID: 26987018

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Author fredrikwermelingPosted on January 15, 2017January 15, 2017

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Recent Posts

  • The Immune Epitope Database!
  • We have deposited our favorite CRISPR screen plasmid @Addgene
  • Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
  • I´ve made a new video about redundant and non-redundant genes in the CRISPR context
  • “Design and analysis of CRISPR-Cas experiments” by Hanna and Doench!
  • Collection of popular scientific texts/observations I have written in the past (in Swedish).
  • Our review “Designing custom CRISPR libraries for hypothesis-driven drug target discovery” is online!
  • Global Immunotalks!
  • Database with validated gRNAs from the Chari lab
  • Interesting study by Orange et al – PRIME Cells Predicting Rheumatoid Arthritis Flares

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